CTNNB1-Mutant Aldosterone-Producing Adenomas With Somatic Mutations of GNA11/GNAQ Have Distinct Phenotype and Genotype

Background: We report (this meeting) somatic mutation of GNA11/Q in CTNNB1-mutant APAs. The recurrent co-driver mutation causes reversible hypertension in puberty, pregnancy, or menopause. We have investigated the molecular mechanism of this association. Methods: Gene expression profiles in 3 double...

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Detalles Bibliográficos
Autores principales: Zhou, Junhua, Boulkroun, Sheerazed, Cabrera, Claudia P, Azizan, Elena A B, Fernandes-Rosa, Fabio, Cottrell, Emily, Argentesi, Giulia, Wu, Xilin, O’Toole, Sam, Marker, Alison, Jordan, Suzanne, Berney, Daniel M, Lines, Kate, Metherell, Louise, Teo, Ada, Thakker, Rajesh V, Drake, William, Wozniak, Eva, Mein, Charles A, Storr, Helen L, Zennaro, Maria-Christina, Brown, Morris J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Adrenal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089757/
http://dx.doi.org/10.1210/jendso/bvab048.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089757/
http://dx.doi.org/10.1210/jendso/bvab048.133

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