Cargando…

Sox2 Is Required Independently in Both Stem and Differentiated Cells for Pituitary Tumour Genesis in P27 Null Mice

Tumour development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we have established a genetically tractable model demonstrating that the same gene is relevant both cell-autonomously and non-cell-autonomously for tumorigenesis. P27, a ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Moncho-Amor, Veronica, Chakravarty, Probir, Galichet, Christophe, Lovell-Badge, Robin, Rizzoti, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090700/
http://dx.doi.org/10.1210/jendso/bvab048.1043