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Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis
Telomere fusions lead to a state of genomic instability, and are thought to drive clonal evolution and tumorigenesis. Telomere fusions occur via both Classical and Alternative Non-Homologous End Joining repair pathways. AsiDNA is a DNA repair inhibitor that acts by mimicking a DNA double strand brea...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091035/ https://www.ncbi.nlm.nih.gov/pubmed/33480989 http://dx.doi.org/10.1093/hmg/ddab008 |