A detailed picture of a protein–carbohydrate hydrogen-bonding network revealed by NMR and MD simulations

Cyanovirin-N (CV-N) is a cyanobacterial lectin with antiviral activity towards HIV and several other viruses. Here, we identify mannoside hydroxyl protons that are hydrogen bonded to the protein backbone of the CV-N domain B binding site, using NMR spectroscopy. For the two carbohydrate ligands Manα...

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Detalles Bibliográficos
Autores principales: Nestor, Gustav, Ruda, Alessandro, Anderson, Taigh, Oscarson, Stefan, Widmalm, Göran, Gronenborn, Angela M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091458/
https://www.ncbi.nlm.nih.gov/pubmed/32902635
http://dx.doi.org/10.1093/glycob/cwaa081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091458/
https://www.ncbi.nlm.nih.gov/pubmed/32902635
http://dx.doi.org/10.1093/glycob/cwaa081

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