Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells

Farnesyltransferase inhibitors (FTIs) suppress tumor aggressiveness in several malignancies by inhibiting Ras signaling. However, treatment of cells with a low dose of the FTI tipifarnib suppresses the expression of hypoxia‐inducible factor‐1α (HIF‐1α) and results in antitumor effects without inhibi...

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Detalles Bibliográficos
Autores principales: Egawa, Noriyuki, Tanaka, Tomokazu, Matsufuji, Shohei, Yamada, Kohei, Ito, Kotaro, Kitagawa, Hiroshi, Okuyama, Keiichiro, Kitajima, Yoshihiko, Noshiro, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091580/
https://www.ncbi.nlm.nih.gov/pubmed/33773069
http://dx.doi.org/10.1002/2211-5463.13154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091580/
https://www.ncbi.nlm.nih.gov/pubmed/33773069
http://dx.doi.org/10.1002/2211-5463.13154

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