Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes

BACKGROUND: Cancer genomes are shaped by mutational processes with complex spatial variation at multiple scales. Entire classes of regulatory elements are affected by local variations in mutation frequency. However, the underlying mechanisms with functional and genetic determinants remain poorly und...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Christian A., Abd-Rabbo, Diala, Reimand, Jüri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091793/
https://www.ncbi.nlm.nih.gov/pubmed/33941236
http://dx.doi.org/10.1186/s13059-021-02318-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091793/
https://www.ncbi.nlm.nih.gov/pubmed/33941236
http://dx.doi.org/10.1186/s13059-021-02318-x

Ejemplares similares