Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling

Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all three members of the YTHDF protein family, cytosolic N(6)-methyladenosine (m(6)A) “readers” that regulate target mRNA fate. YTHDF protein cleava...

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Detalles Bibliográficos
Autores principales: Kastan, Jonathan P., Tremblay, Martine W., Brown, Michael C., Trimarco, Joseph D., Dobrikova, Elena Y., Dobrikov, Mikhail I., Gromeier, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092205/
https://www.ncbi.nlm.nih.gov/pubmed/33849973
http://dx.doi.org/10.1128/mBio.00116-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092205/
https://www.ncbi.nlm.nih.gov/pubmed/33849973
http://dx.doi.org/10.1128/mBio.00116-21

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