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Extreme C-to-A Hypermutation at a Site of Cytosine-N4 Methylation
Methylation of cytosine in DNA at position C5 increases the rate of C→T mutations in bacteria and eukaryotes. Methylation at the N4 position, employed by some restriction-modification systems, is not known to increase the mutation rate. Here, I report that a Salmonella enterica Type III restriction-...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092215/ https://www.ncbi.nlm.nih.gov/pubmed/33849975 http://dx.doi.org/10.1128/mBio.00172-21 |