Hypoxia-Inducible Factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis

Human cytomegalovirus (HCMV) replication depends on the activities of several host regulators of metabolism. Hypoxia-inducible factor 1α (HIF1α) was previously proposed to support virus replication through its metabolic regulatory function. HIF1α protein levels rise in response to HCMV infection in...

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Detalles Bibliográficos
Autores principales: Wise, Lisa M., Xi, Yuecheng, Purdy, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092273/
https://www.ncbi.nlm.nih.gov/pubmed/33758082
http://dx.doi.org/10.1128/mBio.02956-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092273/
https://www.ncbi.nlm.nih.gov/pubmed/33758082
http://dx.doi.org/10.1128/mBio.02956-20

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