Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2

Malignant cells commonly use aerobic glycolysis for ATP production; this is known as the Warburg effect, where pyruvate is converted to lactate, by enzyme lactate dehydrogenase A (LDH-A). In this study, we have investigated the effect of inhibition of LDH-A on cells viability and identifying the mec...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Salam, Suhail, Kandhan, Karthishwaran, Sudhadevi, Manjusha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092341/
https://www.ncbi.nlm.nih.gov/pubmed/33953846
http://dx.doi.org/10.18632/oncotarget.27950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092341/
https://www.ncbi.nlm.nih.gov/pubmed/33953846
http://dx.doi.org/10.18632/oncotarget.27950

Ejemplares similares