Transcription factor allosteric regulation through substrate coordination to zinc

The development of new synthetic biology circuits for biotechnology and medicine requires deeper mechanistic insight into allosteric transcription factors (aTFs). Here we studied the aTF UxuR, a homodimer of two domains connected by a highly flexible linker region. To explore how ligand binding to U...

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Detalles Bibliográficos
Autores principales: Almeida, Beatriz C, Kaczmarek, Jennifer A, Figueiredo, Pedro R, Prather, Kristala L J, Carvalho, Alexandra T P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092373/
https://www.ncbi.nlm.nih.gov/pubmed/33987533
http://dx.doi.org/10.1093/nargab/lqab033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092373/
https://www.ncbi.nlm.nih.gov/pubmed/33987533
http://dx.doi.org/10.1093/nargab/lqab033

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