Transferrin receptor targeting by de novo sheet extension

The de novo design of polar protein–protein interactions is challenging because of the thermodynamic cost of stripping water away from the polar groups. Here, we describe a general approach for designing proteins which complement exposed polar backbone groups at the edge of beta sheets with geometri...

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Detalles Bibliográficos
Autores principales: Sahtoe, Danny D., Coscia, Adrian, Mustafaoglu, Nur, Miller, Lauren M., Olal, Daniel, Vulovic, Ivan, Yu, Ta-Yi, Goreshnik, Inna, Lin, Yu-Ru, Clark, Lars, Busch, Florian, Stewart, Lance, Wysocki, Vicki H., Ingber, Donald E., Abraham, Jonathan, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092486/
https://www.ncbi.nlm.nih.gov/pubmed/33879614
http://dx.doi.org/10.1073/pnas.2021569118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092486/
https://www.ncbi.nlm.nih.gov/pubmed/33879614
http://dx.doi.org/10.1073/pnas.2021569118

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