Cargando…
A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
Global infections by nontuberculous mycobacteria (NTM) are steadily rising. New drugs are needed to treat NTM infections, but the NTM drug pipeline remains poorly populated and focused on repurposing or reformulating approved antibiotics. We sought to accelerate de novo NTM drug discovery by testing...
Autores principales: | Ganapathy, Uday S., González del Rio, Rubén, Cacho-Izquierdo, Mónica, Ortega, Fátima, Lelièvre, Joël, Barros-Aguirre, David, Lindman, Marissa, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092876/ https://www.ncbi.nlm.nih.gov/pubmed/33558292 http://dx.doi.org/10.1128/AAC.02420-20 |
Ejemplares similares
-
A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus
por: Ganapathy, Uday S., et al.
Publicado: (2021) -
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection
por: Negatu, Dereje A., et al.
Publicado: (2023) -
Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase
por: Palencia, Andrés, et al.
Publicado: (2016) -
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
por: Palencia, Andrés, et al.
Publicado: (2016) -
First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment
por: Tenero, David, et al.
Publicado: (2019)