Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation

Long noncoding RNAs (lncRNAs) are known to play a key role in chronic myelocytic leukemia (CML) development, and we aimed to identify the involvement of the lncRNA HOX antisense intergenic RNA (HOTAIR) in CML via binding to DNA methyltransferase 1 (DNMT1) to accelerate methylation of the phosphatase...

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Detalles Bibliográficos
Autores principales: Song, Haiping, Chen, Lijuan, Liu, Wei, Xu, Xiaoli, Zhou, Yongming, Zhu, Jianhua, Chen, Xuexing, Li, Ziping, Zhou, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093289/
https://www.ncbi.nlm.nih.gov/pubmed/33941772
http://dx.doi.org/10.1038/s41419-021-03637-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093289/
https://www.ncbi.nlm.nih.gov/pubmed/33941772
http://dx.doi.org/10.1038/s41419-021-03637-4

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