Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics

Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system. As part of their humoral adaptive immune response, they produce an immunoglobulin, the so-called immunoglobulin new antigen receptor (IgNAR), a heavy-cha...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Seidler, Clarissa A., Quoika, Patrick K., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093575/
https://www.ncbi.nlm.nih.gov/pubmed/33959632
http://dx.doi.org/10.3389/fmolb.2021.639166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093575/
https://www.ncbi.nlm.nih.gov/pubmed/33959632
http://dx.doi.org/10.3389/fmolb.2021.639166

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