A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane

Activity of the endo-beta-glucuronidase heparanase, capable of cleaving heparan sulfate (HS), is most often elevated in many types of tumors, associating with increased tumor metastasis and decreased patients’ survival. Heparanase is therefore considered to be a valid drug target, and heparanase inh...

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Detalles Bibliográficos
Autores principales: Margulis, Itai, Naroditsky, Inna, Gross-Cohen, Miriam, Ilan, Neta, Vlodavsky, Israel, Doweck, Ilana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093622/
https://www.ncbi.nlm.nih.gov/pubmed/33959505
http://dx.doi.org/10.3389/fonc.2021.645524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093622/
https://www.ncbi.nlm.nih.gov/pubmed/33959505
http://dx.doi.org/10.3389/fonc.2021.645524

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