From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). This modality has emerged as an orthogonal approach to the use of small-molecule inhibitors for knocking down classic targets an...

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Detalles Bibliográficos
Autores principales: Cecchini, Carlotta, Pannilunghi, Sara, Tardy, Sébastien, Scapozza, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093871/
https://www.ncbi.nlm.nih.gov/pubmed/33959589
http://dx.doi.org/10.3389/fchem.2021.672267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093871/
https://www.ncbi.nlm.nih.gov/pubmed/33959589
http://dx.doi.org/10.3389/fchem.2021.672267

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