Cargando…
From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). This modality has emerged as an orthogonal approach to the use of small-molecule inhibitors for knocking down classic targets an...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093871/ https://www.ncbi.nlm.nih.gov/pubmed/33959589 http://dx.doi.org/10.3389/fchem.2021.672267 |