Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146

CD146 is an adhesion molecule that plays important roles in angiogenesis, cancer metastasis, and immune response. It exists as a monomer or dimer on the cell surface. AA98 is a monoclonal antibody that binds to CD146, which abrogates the activation of CD146-mediated signaling pathways and shows inhi...

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Detalles Bibliográficos
Autores principales: Chen, Xuehui, Yan, Huiwen, Liu, Dan, Xu, Qingji, Duan, Hongxia, Feng, Jing, Yan, Xiyun, Xie, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093899/
https://www.ncbi.nlm.nih.gov/pubmed/33997697
http://dx.doi.org/10.1016/j.isci.2021.102417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093899/
https://www.ncbi.nlm.nih.gov/pubmed/33997697
http://dx.doi.org/10.1016/j.isci.2021.102417

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