Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain

Expression of Inhibitory PAS domain protein (IPAS) induces apoptosis by inhibiting the anti-apoptotic activity of mitochondrial pro-survival proteins including Bcl-x(L) and Mcl-1 through direct binding. Analysis to examine the IPAS-binding region in Bcl-x(L) demonstrated that the C-terminal transmem...

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Detalles Bibliográficos
Autores principales: Kasai, Shuya, Yasumoto, Ken-ichi, Sogawa, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093901/
https://www.ncbi.nlm.nih.gov/pubmed/33947838
http://dx.doi.org/10.1038/s41420-021-00475-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093901/
https://www.ncbi.nlm.nih.gov/pubmed/33947838
http://dx.doi.org/10.1038/s41420-021-00475-3

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