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Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain
Expression of Inhibitory PAS domain protein (IPAS) induces apoptosis by inhibiting the anti-apoptotic activity of mitochondrial pro-survival proteins including Bcl-x(L) and Mcl-1 through direct binding. Analysis to examine the IPAS-binding region in Bcl-x(L) demonstrated that the C-terminal transmem...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093901/ https://www.ncbi.nlm.nih.gov/pubmed/33947838 http://dx.doi.org/10.1038/s41420-021-00475-3 |