Collagen IV(α345) dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture’s disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-in mice. To understand the context of this “Zurich”...

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Detalles Bibliográficos
Autores principales: Boudko, Sergei P., Bauer, Ryan, Chetyrkin, Sergei V., Ivanov, Sergey, Smith, Jarrod, Voziyan, Paul A., Hudson, Billy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093946/
https://www.ncbi.nlm.nih.gov/pubmed/33775698
http://dx.doi.org/10.1016/j.jbc.2021.100591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093946/
https://www.ncbi.nlm.nih.gov/pubmed/33775698
http://dx.doi.org/10.1016/j.jbc.2021.100591

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