Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome

POEMS syndrome is a rare plasma cell dyscrasia with distinct lipid metabolism abnormalities at disease onset. However, the serum lipidomic characteristics in patients with POEMS syndrome were not investigated. The study performed an untargeted lipidome screening by liquid chromatography‐tandem mass...

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Autores principales: Zhao, Hao, Gao, Xue‐min, Cao, Xin‐xin, Zhang, Lu, Zhou, Dao‐bin, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093959/
https://www.ncbi.nlm.nih.gov/pubmed/33779058
http://dx.doi.org/10.1111/jcmm.16486
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author Zhao, Hao
Gao, Xue‐min
Cao, Xin‐xin
Zhang, Lu
Zhou, Dao‐bin
Li, Jian
author_facet Zhao, Hao
Gao, Xue‐min
Cao, Xin‐xin
Zhang, Lu
Zhou, Dao‐bin
Li, Jian
author_sort Zhao, Hao
collection PubMed
description POEMS syndrome is a rare plasma cell dyscrasia with distinct lipid metabolism abnormalities at disease onset. However, the serum lipidomic characteristics in patients with POEMS syndrome were not investigated. The study performed an untargeted lipidome screening by liquid chromatography‐tandem mass spectrometry (LS‐MS/MS) in the pre‐ and post‐treatment serum of 24 patients with POEMS syndrome, together with the serum of 24 paired healthy controls. Patients with POEMS syndrome had a distinct serum lipid composition compared with healthy controls, and a 3‐lipid model had a predictive accuracy of 93.5% in distinguishing patients and healthy controls consisting of fatty acyl 17‐oxo‐20Z‐hexacosenoic acid, phosphatidylcholine(16:0/18:1(9Z)) and sterol lipid 5b‐pregnanediol. Four lipids including 17‐oxo‐20Z‐hexacosenoic acid (r = 0.423, P = .040) were correlated with risk stratification, and 2 lipids including Cer(d18:0/13:0) were inversely related to serum vascular endothelial growth factor level (r=−0.465, P = .022). Eleven lipids were related to disease activity, including arachidonic acid which was inversely related and lysoPC(20:4) which was positively related. The study indicated a distinct lipid characteristic profile of patients with POEMS syndrome different from healthy controls and identified several lipids that may serve as potential diagnostic markers and monitors of therapeutic efficacy, as well as indicating potential metabolism pathways involved in the pathological process.
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spelling pubmed-80939592021-05-10 Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome Zhao, Hao Gao, Xue‐min Cao, Xin‐xin Zhang, Lu Zhou, Dao‐bin Li, Jian J Cell Mol Med Original Articles POEMS syndrome is a rare plasma cell dyscrasia with distinct lipid metabolism abnormalities at disease onset. However, the serum lipidomic characteristics in patients with POEMS syndrome were not investigated. The study performed an untargeted lipidome screening by liquid chromatography‐tandem mass spectrometry (LS‐MS/MS) in the pre‐ and post‐treatment serum of 24 patients with POEMS syndrome, together with the serum of 24 paired healthy controls. Patients with POEMS syndrome had a distinct serum lipid composition compared with healthy controls, and a 3‐lipid model had a predictive accuracy of 93.5% in distinguishing patients and healthy controls consisting of fatty acyl 17‐oxo‐20Z‐hexacosenoic acid, phosphatidylcholine(16:0/18:1(9Z)) and sterol lipid 5b‐pregnanediol. Four lipids including 17‐oxo‐20Z‐hexacosenoic acid (r = 0.423, P = .040) were correlated with risk stratification, and 2 lipids including Cer(d18:0/13:0) were inversely related to serum vascular endothelial growth factor level (r=−0.465, P = .022). Eleven lipids were related to disease activity, including arachidonic acid which was inversely related and lysoPC(20:4) which was positively related. The study indicated a distinct lipid characteristic profile of patients with POEMS syndrome different from healthy controls and identified several lipids that may serve as potential diagnostic markers and monitors of therapeutic efficacy, as well as indicating potential metabolism pathways involved in the pathological process. John Wiley and Sons Inc. 2021-03-28 2021-05 /pmc/articles/PMC8093959/ /pubmed/33779058 http://dx.doi.org/10.1111/jcmm.16486 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhao, Hao
Gao, Xue‐min
Cao, Xin‐xin
Zhang, Lu
Zhou, Dao‐bin
Li, Jian
Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome
title Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome
title_full Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome
title_fullStr Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome
title_full_unstemmed Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome
title_short Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome
title_sort revealing serum lipidomic characteristics and potential lipid biomarkers in patients with poems syndrome
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093959/
https://www.ncbi.nlm.nih.gov/pubmed/33779058
http://dx.doi.org/10.1111/jcmm.16486
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