The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H

Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b. UMOD, an N‐glycans‐rich glycoprotein, is expressed in thick ascending limb of Henle's loop where the epithelia...

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Detalles Bibliográficos
Autores principales: Bai, Lufeng, Xie, Qiuyu, Xia, Min, Gong, Kunjing, Wang, Na, Chen, Yuqing, Zhao, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093974/
https://www.ncbi.nlm.nih.gov/pubmed/33788378
http://dx.doi.org/10.1111/jcmm.16492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093974/
https://www.ncbi.nlm.nih.gov/pubmed/33788378
http://dx.doi.org/10.1111/jcmm.16492

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