Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction

Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE(2) secretion. To elucidate the role of the LSEC intercellular adhesion molecule-1 (ICAM-1...

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Detalles Bibliográficos
Autores principales: Herrero, Alba, Benedicto, Aitor, Romayor, Irene, Olaso, Elvira, Arteta, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094073/
https://www.ncbi.nlm.nih.gov/pubmed/33455946
http://dx.doi.org/10.4062/biomolther.2020.160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094073/
https://www.ncbi.nlm.nih.gov/pubmed/33455946
http://dx.doi.org/10.4062/biomolther.2020.160

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