Individualized dosing guidelines for PEGasparaginase and factors influencing the clearance: a population pharmacokinetic model

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Considerable inter- and intra-patient variability exist in serum activity levels of PEGasparaginase, essential for pediatric acute lymphoblastic leukemia (ALL) treatment. A population pharmacokinetic (popPK) model was developed, identifying patient characteristics that explain these variabilities. P...

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Detalles Bibliográficos
Autores principales: Kloos, Robin Q.H., Mathôt, Ron, Pieters, Rob, van der Sluis, Inge M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094082/
https://www.ncbi.nlm.nih.gov/pubmed/32327497
http://dx.doi.org/10.3324/haematol.2019.242289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094082/
https://www.ncbi.nlm.nih.gov/pubmed/32327497
http://dx.doi.org/10.3324/haematol.2019.242289

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