Targeting the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Tumor immunosuppression is a major cause of treatment failure and disease relapse, both in solid tumors and leukemia. Local hypoxia is among the conditions that cause immunosuppression, acting at least in part through the upregulation of extracellular adenosine levels, which potently suppress T-cell...

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Detalles Bibliográficos
Autores principales: Arruga, Francesca, Serra, Sara, Vitale, Nicoletta, Guerra, Giulia, Papait, Andrea, Gyau, Benjamin Baffour, Tito, Francesco, Efremov, Dimitar, Vaisitti, Tiziana, Deaglio, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094100/
https://www.ncbi.nlm.nih.gov/pubmed/32299906
http://dx.doi.org/10.3324/haematol.2019.242016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094100/
https://www.ncbi.nlm.nih.gov/pubmed/32299906
http://dx.doi.org/10.3324/haematol.2019.242016

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