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Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. A complete understanding of adaptive compensatory metabolic programmes that modulate non-alc...

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Detalles Bibliográficos
Autores principales: Azzu, Vian, Vacca, Michele, Kamzolas, Ioannis, Hall, Zoe, Leslie, Jack, Carobbio, Stefania, Virtue, Samuel, Davies, Susan E., Lukasik, Agnes, Dale, Martin, Bohlooly-Y, Mohammad, Acharjee, Animesh, Lindén, Daniel, Bidault, Guillaume, Petsalaki, Evangelia, Griffin, Julian L., Oakley, Fiona, Allison, Michael E.D., Vidal-Puig, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094910/
https://www.ncbi.nlm.nih.gov/pubmed/33722690
http://dx.doi.org/10.1016/j.molmet.2021.101210