κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent rats and in animal models of chronic pain. However,...

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Detalles Bibliográficos
Autores principales: Marchette, Renata C.N., Gregory-Flores, Adriana, Tunstall, Brendan J., Carlson, Erika R., Jackson, Shelley N., Sulima, Agnieszka, Rice, Kenner C., Koob, George F., Vendruscolo, Leandro F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095052/
https://www.ncbi.nlm.nih.gov/pubmed/33997152
http://dx.doi.org/10.1016/j.ynstr.2021.100325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095052/
https://www.ncbi.nlm.nih.gov/pubmed/33997152
http://dx.doi.org/10.1016/j.ynstr.2021.100325

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