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κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent rats and in animal models of chronic pain. However,...

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Detalles Bibliográficos
Autores principales:	Marchette, Renata C.N., Gregory-Flores, Adriana, Tunstall, Brendan J., Carlson, Erika R., Jackson, Shelley N., Sulima, Agnieszka, Rice, Kenner C., Koob, George F., Vendruscolo, Leandro F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095052/ https://www.ncbi.nlm.nih.gov/pubmed/33997152 http://dx.doi.org/10.1016/j.ynstr.2021.100325

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