Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides

The catalytic subunit of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), Nsp12, has a unique NiRAN domain that transfers nucleoside monophosphates to the Nsp9 protein. The NiRAN and RdRp modules form a dynamic interface distant from their catalytic sites and both activities are essential for viral r...

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Detalles Bibliográficos
Autores principales: Wang, Bing, Svetlov, Vladimir, Wolf, Yuri I, Koonin, Eugene V, Nudler, Evgeny, Artsimovitch, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095223/
https://www.ncbi.nlm.nih.gov/pubmed/33948598
http://dx.doi.org/10.1101/2021.01.24.428004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095223/
https://www.ncbi.nlm.nih.gov/pubmed/33948598
http://dx.doi.org/10.1101/2021.01.24.428004

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