Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) by selectively targeting lipopolysaccharide (LPS), it was unclear how this led to bacterial killing. We discover...

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Detalles Bibliográficos
Autores principales: Sabnis, Akshay, Hagart, Katheryn LH, Klöckner, Anna, Becce, Michele, Evans, Lindsay E, Furniss, R Christopher D, Mavridou, Despoina AI, Murphy, Ronan, Stevens, Molly M, Davies, Jane C, Larrouy-Maumus, Gérald J, Clarke, Thomas B, Edwards, Andrew M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096433/
https://www.ncbi.nlm.nih.gov/pubmed/33821795
http://dx.doi.org/10.7554/eLife.65836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096433/
https://www.ncbi.nlm.nih.gov/pubmed/33821795
http://dx.doi.org/10.7554/eLife.65836

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