Cargando…

APOE and Alzheimer’s Disease: Advances in Genetics, Pathophysiology, and Therapeutic Approaches.

The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer’s disease and the APOE ε2 allele the strongest genetic protective factor after multiple large scale genome-wide association studies and genome-wide association meta-analyses. However, no therapies directed at APOE ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Serrano-Pozo, Alberto, Das, Sudeshna, Hyman, Bradley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096522/ https://www.ncbi.nlm.nih.gov/pubmed/33340485 http://dx.doi.org/10.1016/S1474-4422(20)30412-9

Ejemplares similares

Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease
por: Qian, Jing, et al.
Publicado: (2021)

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains
por: Gui, Yaxing, et al.
Publicado: (2019)

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
por: Raulin, Ana-Caroline, et al.
Publicado: (2022)

Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum
por: Noori, Ayush, et al.
Publicado: (2021)

Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease
por: Viejo, Lucía, et al.
Publicado: (2021)

Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum
por: Qian, Jing, et al.
Publicado: (2023)

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
por: Das, Sudeshna, et al.
Publicado: (2020)

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration
por: Noori, Ayush, et al.
Publicado: (2020)

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
por: Muñoz-Castro, Clara, et al.
Publicado: (2022)

Roles of ApoE4 on the Pathogenesis in Alzheimer’s Disease and the Potential Therapeutic Approaches
por: Sun, Yu-Ying, et al.
Publicado: (2023)

APOE allele frequencies in suspected non-amyloid pathophysiology (SNAP) and the prodromal stages of Alzheimer’s Disease
por: Hohman, Timothy J., et al.
Publicado: (2017)

Calcium Signalling in Alzheimer’s Disease: From Pathophysiological Regulation to Therapeutic Approaches
por: Chami, Mounia
Publicado: (2021)

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease
por: Bryant, Annie, et al.
Publicado: (2023)

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease
por: Tai, Hwan-Ching, et al.
Publicado: (2014)

Genetic and regulatory architecture of Alzheimer's disease in the APOE region
por: Kulminski, Alexander M., et al.
Publicado: (2020)

APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics
por: Husain, Mohammed Amir, et al.
Publicado: (2021)

ApoE4: an emerging therapeutic target for Alzheimer’s disease
por: Safieh, Mirna, et al.
Publicado: (2019)

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease
por: Li, Zonghua, et al.
Publicado: (2020)

ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease
por: Lanfranco, Maria Fe, et al.
Publicado: (2020)

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
por: Fernández-Calle, Rosalía, et al.
Publicado: (2022)

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology
por: Tran, Tam T. T., et al.
Publicado: (2019)

Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease
por: Mamun, Abdullah Al, et al.
Publicado: (2020)

Genetic Cross-Interaction between APOE and PRNP in Sporadic Alzheimer's and Creutzfeldt-Jakob Diseases
por: Calero, Olga, et al.
Publicado: (2011)

Perspectives on the Role of APOE4 as a Therapeutic Target for Alzheimer’s Disease
por: Patel, Kavita, et al.
Publicado: (2021)

The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions
por: Hunsberger, Holly C., et al.
Publicado: (2019)

Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targets
por: Zhang, Lan, et al.
Publicado: (2023)

Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease
por: Kim, Young Won, et al.
Publicado: (2020)

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
por: Bryant, Annie G., et al.
Publicado: (2020)

The genetic risk of Alzheimer’s disease beyond APOE ε4: systematic review of Alzheimer’s genetic risk scores
por: Stocker, Hannah, et al.
Publicado: (2018)

Pathophysiology and therapeutic advances in myeloma bone disease
por: Zhang, Fujing, et al.
Publicado: (2022)

Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies
por: Pires, Mariana, et al.
Publicado: (2023)

Similar Genetic Architecture of Alzheimer’s Disease and Differential APOE Effect Between Sexes
por: Wang, Hao, et al.
Publicado: (2021)

The Role of Upregulated APOE in Alzheimer’s Disease Etiology
por: Gottschalk, William K, et al.
Publicado: (2016)

Deciphering the Astrocyte Reaction in Alzheimer’s Disease
por: Perez-Nievas, Beatriz G., et al.
Publicado: (2018)

Editorial: The Role of Glia in Alzheimer's Disease
por: Pérez-Nievas, Beatriz G., et al.
Publicado: (2019)

Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors
por: Bu, Guojun, et al.
Publicado: (2013)

Alzheimer’s disease: Pathophysiology and dental pulp stem cells therapeutic prospects
por: Xiong, Wei, et al.
Publicado: (2022)

Variation at APOE and STH loci and Alzheimer's disease
por: Zuo, Lingjun, et al.
Publicado: (2006)

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
por: Hinrich, Anthony J, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_s5f3jr4osrfr8r8ubajrmqg9sh