Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing method for solubility and bioavailability enhancement of drugs

In this study, drug-cyclodextrin (CD) complexes were prepared using hot liquid extrusion (HLE) process with an aim to improve solubility and bioavailability of carbamazepine. Saturation solubility studies of CBZ in water and different pH media showed a pH-independent solubility. Phase solubility stu...

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Detalles Bibliográficos
Autores principales: Manne, Alekhya Sri Nagini, Hegde, Aswathi R, Raut, Sushil Yadaorao, Rao, Rajat Radhakrishna, Kulkarni, Vijay Induvadan, Mutalik, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096738/
https://www.ncbi.nlm.nih.gov/pubmed/32959332
http://dx.doi.org/10.1007/s13346-020-00854-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096738/
https://www.ncbi.nlm.nih.gov/pubmed/32959332
http://dx.doi.org/10.1007/s13346-020-00854-w

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