High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs

Reverse transcription of the HIV-1 viral RNA genome (vRNA) is an integral step in virus replication. Upon viral entry, HIV-1 reverse transcriptase (RT) initiates from a host tRNA(Lys)(3) primer bound to the vRNA genome and is the target of key antivirals, such as non-nucleoside reverse transcriptase...

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Detalles Bibliográficos
Autores principales: Ha, Betty, Larsen, Kevin P., Zhang, Jingji, Fu, Ziao, Montabana, Elizabeth, Jackson, Lynnette N., Chen, Dong-Hua, Puglisi, Elisabetta Viani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096811/
https://www.ncbi.nlm.nih.gov/pubmed/33947853
http://dx.doi.org/10.1038/s41467-021-22628-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096811/
https://www.ncbi.nlm.nih.gov/pubmed/33947853
http://dx.doi.org/10.1038/s41467-021-22628-9

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