Non-coding RNA suppresses FUS aggregation caused by mechanistic shear stress on pipetting in a sequence-dependent manner

Fused in sarcoma/translocated in liposarcoma (FUS/TLS) is a multitasking RNA/DNA binding protein. FUS aggregation is implicated in various neurodegenerative diseases. RNA was suggested to modulate phase transition of FUS. Here, we found that FUS transforms into the amorphous aggregation state as an...

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Detalles Bibliográficos
Autores principales: Hamad, Nesreen, Yoneda, Ryoma, So, Masatomo, Kurokawa, Riki, Nagata, Takashi, Katahira, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096841/
https://www.ncbi.nlm.nih.gov/pubmed/33947944
http://dx.doi.org/10.1038/s41598-021-89075-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096841/
https://www.ncbi.nlm.nih.gov/pubmed/33947944
http://dx.doi.org/10.1038/s41598-021-89075-w

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