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GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma
Pheochromocytoma/paraganglioma (PPGL) is an endocrine tumor of the chromaffin cells in the adrenal medulla or the paraganglia. Currently, about 70% of PPGLs can be explained by germline or somatic mutations in several broadly expressed susceptibility genes including RET, VHL, and SDHB, while for the...
Autores principales: | Dong, Yeqing, Huang, Yongsheng, Fan, Chengyan, Wang, Liang, Zhang, Ran, Li, Wenhua, Guo, Zhengguang, Wang, Dong, Zheng, Zhi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096975/ https://www.ncbi.nlm.nih.gov/pubmed/33947839 http://dx.doi.org/10.1038/s41419-021-03731-7 |
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