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Gene-environment dependencies lead to collider bias in models with polygenic scores
The application of polygenic scores has transformed our ability to investigate whether and how genetic and environmental factors jointly contribute to the variation of complex traits. Modelling the complex interplay between genes and environment, however, raises serious methodological challenges. He...
Autores principales: | Akimova, Evelina T., Breen, Richard, Brazel, David M., Mills, Melinda C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097011/ https://www.ncbi.nlm.nih.gov/pubmed/33947934 http://dx.doi.org/10.1038/s41598-021-89020-x |
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