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Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial

Immunization with Plasmodium falciparum (Pf) sporozoites under chemoprophylaxis (PfSPZ-CVac) is the most efficacious approach to malaria vaccination. Implementation is hampered by a complex chemoprophylaxis regimen and missing evidence for efficacy against heterologous infection. We report the resul...

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Detalles Bibliográficos
Autores principales: Sulyok, Zita, Fendel, Rolf, Eder, Bianca, Lorenz, Freia-Raphaella, KC, Natasha, Karnahl, Matthias, Lalremruata, Albert, Nguyen, The T., Held, Jana, Adjadi, Folashade Almeine Cyntiche, Klockenbring, Torsten, Flügge, Judith, Woldearegai, Tamirat Gebru, Lamsfus Calle, Carlos, Ibáñez, Javier, Rodi, Miriam, Egger-Adam, Diane, Kreidenweiss, Andrea, Köhler, Carsten, Esen, Meral, Sulyok, Mihály, Manoj, Anita, Richie, Thomas L., Sim, B. Kim Lee, Hoffman, Stephen L., Mordmüller, Benjamin, Kremsner, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097064/
https://www.ncbi.nlm.nih.gov/pubmed/33947856
http://dx.doi.org/10.1038/s41467-021-22740-w