Hypoxia-inducible factor-1α regulates PI3K/AKT signaling through microRNA-32-5p/PTEN and affects nucleus pulposus cell proliferation and apoptosis

Intervertebral disc degeneration and resulting low back pain arises from the programmed apoptosis of nucleus pulposus cells (NPCs). Recent studies show that hypoxia-inducible factor-1α plays a vital role in the etiology and pathogenesis of disc degeneration. However, the underlying mechanism of HIF-...

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Detalles Bibliográficos
Autores principales: Zhan, Daolu, Lin, Mingxia, Chen, Jian, Cai, Wentao, Liu, Jian, Fang, Yehan, Li, Yibo, Wu, Bin, Wang, Guangji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097185/
https://www.ncbi.nlm.nih.gov/pubmed/33968177
http://dx.doi.org/10.3892/etm.2021.10078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097185/
https://www.ncbi.nlm.nih.gov/pubmed/33968177
http://dx.doi.org/10.3892/etm.2021.10078

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