USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling

The tumour suppressors RNF43 and ZNRF3 play a central role in development and tissue homeostasis by promoting the turnover of the Wnt receptors LRP6 and Frizzled (FZD). The stem cell growth factor R‐spondin induces auto‐ubiquitination and membrane clearance of ZNRF3/RNF43 to promote Wnt signalling....

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Detalles Bibliográficos
Autores principales: Giebel, Nicole, de Jaime‐Soguero, Anchel, García del Arco, Ana, Landry, Jonathan J M, Tietje, Marlene, Villacorta, Laura, Benes, Vladimir, Fernández‐Sáiz, Vanesa, Acebrón, Sergio P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097334/
https://www.ncbi.nlm.nih.gov/pubmed/33786993
http://dx.doi.org/10.15252/embr.202051415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097334/
https://www.ncbi.nlm.nih.gov/pubmed/33786993
http://dx.doi.org/10.15252/embr.202051415

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