Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures

Defects in DNA single‐strand break repair (SSBR) are linked with neurological dysfunction but the underlying mechanisms remain poorly understood. Here, we show that hyperactivity of the DNA strand break sensor protein Parp1 in mice in which the central SSBR protein Xrcc1 is conditionally deleted (Xr...

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Detalles Bibliográficos
Autores principales: Komulainen, Emilia, Badman, Jack, Rey, Stephanie, Rulten, Stuart, Ju, Limei, Fennell, Kate, Kalasova, Ilona, Ilievova, Kristyna, McKinnon, Peter J, Hanzlikova, Hana, Staras, Kevin, Caldecott, Keith W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097344/
https://www.ncbi.nlm.nih.gov/pubmed/33932076
http://dx.doi.org/10.15252/embr.202051851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097344/
https://www.ncbi.nlm.nih.gov/pubmed/33932076
http://dx.doi.org/10.15252/embr.202051851

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