Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1

Polyunsaturated fatty acids (PUFAs), but not saturated fatty acids, modulate ion channels such as the cardiac KCNQ1 channel, although the mechanism is not completely understood. Using both simulations and experiments, we find that PUFAs interact directly with the KCNQ1 channel via two different bind...

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Detalles Bibliográficos
Autores principales: Yazdi, Samira, Nikesjö, Johan, Miranda, Williams, Corradi, Valentina, Tieleman, D. Peter, Noskov, Sergei Yu., Larsson, H. Peter, Liin, Sara I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097404/
https://www.ncbi.nlm.nih.gov/pubmed/33939797
http://dx.doi.org/10.1085/jgp.202012850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097404/
https://www.ncbi.nlm.nih.gov/pubmed/33939797
http://dx.doi.org/10.1085/jgp.202012850

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