Cargando…

Drug-Drug Interaction Study of Benznidazole and E1224 in Healthy Male Volunteers

E1224 is a prodrug of ravuconazole (RVZ), an antifungal drug with promising anti-Trypanosoma cruzi activity, the causative organism of Chagas disease (CD). This study was designed to assess the pharmacokinetics (PK) and safety interactions of benznidazole (BNZ), the drug of choice for treatment of C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ribeiro, Isabela, Blum, Bethania, Fernandes, Jayme, Santina, Glaucia, Asada, Makoto, Everson, Michael, Schuck, Edgar, Feleder, Ethel, Evene, Eric, Gualano, Virginie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Clinical Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097458/ https://www.ncbi.nlm.nih.gov/pubmed/33558286 http://dx.doi.org/10.1128/AAC.02150-19

Ejemplares similares

Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice
por: Diniz, Lívia de Figueiredo, et al.
Publicado: (2018)

Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease
por: Vilar-Pereira, Glaucia, et al.
Publicado: (2016)

Clinical Drug–Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects
por: Ishii, Yasuyuki, et al.
Publicado: (2018)

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease
por: Francisco, Amanda Fortes, et al.
Publicado: (2018)

Optical Absorption of the Antitrypanocidal Drug Benznidazole in Water
por: Bezerra, Eveline M., et al.
Publicado: (2014)

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole
por: Téllez, Jair, et al.
Publicado: (2019)

Benznidazole
por: Soares-Sobrinho, José Lamartine, et al.
Publicado: (2008)

Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers
por: Jun, Soo Youn, et al.
Publicado: (2017)

From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease
por: Gomes, Daniele Cavalcante, et al.
Publicado: (2023)

Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment
por: Galindo Bedor, Danilo César, et al.
Publicado: (2018)

Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole
por: Buschini, Annamaria, et al.
Publicado: (2009)

Alzheimer’s Disease: Understanding Its Novel Drug Delivery Systems and Treatments
por: Dhingra, Hitaansh, et al.
Publicado: (2022)

Prevalence of potential drug–drug interactions in cancer patients treated with oral anticancer drugs
por: van Leeuwen, R W F, et al.
Publicado: (2013)

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole
por: Campos, Mônica C., et al.
Publicado: (2017)

Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies
por: Tarral, Antoine, et al.
Publicado: (2014)

1224. Drug-Resistance Dynamics of Staphylococcus aureus at a Tertiary Hospital, Beijing, China: 2013–2017
por: Zhang, Yuzheng, et al.
Publicado: (2018)

Preclinical pharmacokinetics of benznidazole.
por: Workman, P., et al.
Publicado: (1984)

Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy
por: Farani, Priscila Silva Grijó, et al.
Publicado: (2021)

A prospective study of adverse drug reactions to antiepileptic drugs in children
por: Anderson, Mark, et al.
Publicado: (2015)

Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation
por: Altcheh, Jaime, et al.
Publicado: (2023)

Adherence to statin or aspirin or both in patients with established cardiovascular disease: exploring healthy behaviour vs. drug effects and 10-year follow-up of outcome
por: Wei, Li, et al.
Publicado: (2008)

The Need for Uniformity in the Quality of Drugs
Publicado: (1908)

Predicting the risk of drug–drug interactions in psychiatric hospitals: a retrospective longitudinal pharmacovigilance study
por: Wolff, Jan, et al.
Publicado: (2021)

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance
por: Almeida-Silva, Juliana, et al.
Publicado: (2022)

Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment
por: Radohery, Georges F. R., et al.
Publicado: (2022)

Evaluation of the Prevalence and Risk Factors of Drug-Related Problems in Hypertension and Type 2 Diabetes Mellitus Patients at a Tertiary Care Hospital: A Cross-Sectional Study
por: Reddy Peddi, Divya, et al.
Publicado: (2023)

The Role and Mechanism of microRNA-1224 in Human Cancer
por: Ma, Mingwei, et al.
Publicado: (2022)

What Becomes of Some Spoiled Drugs
Publicado: (1899)

Hepatotoxicity in Mice of a Novel Anti-parasite Drug Candidate Hydroxymethylnitrofurazone: A Comparison with Benznidazole
por: Davies, Carolina, et al.
Publicado: (2014)

Differences in drug utilisation between men and women: a cross-sectional analysis of all dispensed drugs in Sweden
por: Loikas, Desirée, et al.
Publicado: (2013)

Effect of non-steroidal anti-inflammatory drugs on colon carcinoma Caco-2 cell responsiveness to topoisomerase inhibitor drugs
por: Ricchi, P, et al.
Publicado: (2002)

Defining the Antimalarial Activity of Cipargamin in Healthy Volunteers Experimentally Infected with Blood-Stage Plasmodium falciparum
por: McCarthy, James S., et al.
Publicado: (2021)

Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers
por: Hodges, Michael R., et al.
Publicado: (2023)

Comparative drug screening in NUT midline carcinoma
por: Beesley, A H, et al.
Publicado: (2014)

Notes on Some Remedies. XIII. Drugs in Syphilis
por: Chaudhuri, R. N.
Publicado: (1947)

Notes on Some Remedies. XVII. Drugs in Anæmias
por: Chaudhuri, R. N.
Publicado: (1948)

An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment
por: Francis, Jose, et al.
Publicado: (2020)

Surveillance of adverse drug reactions at an adverse drug reaction monitoring centre in Central India: a 7-year surveillance study
por: Sharma, Megha, et al.
Publicado: (2021)

Drug-Associated Risk Tool: development and validation of a self-assessment questionnaire to screen for hospitalised patients at risk for drug-related problems
por: Kaufmann, Carole P, et al.
Publicado: (2018)

Characterization of Differentially Detectable Mycobacterium tuberculosis in the Sputum of Subjects with Drug-Sensitive or Drug-Resistant Tuberculosis before and after Two Months of Therapy
por: Zainabadi, Kayvan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rbcjj0d0a8pqo6f87fd00ia66b