Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria

Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consideration for other antimalarial combination therapies. The aim of this study was to develop a pharmacokinetic-pharmacodynamic model that might...

Descripción completa

Detalles Bibliográficos
Autores principales: Wattanakul, Thanaporn, Baker, Mark, Mohrle, Joerg, McWhinney, Brett, Hoglund, Richard M., McCarthy, James S., Tarning, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097471/
https://www.ncbi.nlm.nih.gov/pubmed/33468477
http://dx.doi.org/10.1128/AAC.01583-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097471/
https://www.ncbi.nlm.nih.gov/pubmed/33468477
http://dx.doi.org/10.1128/AAC.01583-20

Ejemplares similares