Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth

Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial translation. Here we explore the therapeutic potential of targeting mitochondrial translation and report the results of high-conte...

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Detalles Bibliográficos
Autores principales: Sighel, Denise, Notarangelo, Michela, Aibara, Shintaro, Re, Angela, Ricci, Gianluca, Guida, Marianna, Soldano, Alessia, Adami, Valentina, Ambrosini, Chiara, Broso, Francesca, Rosatti, Emanuele Filiberto, Longhi, Sara, Buccarelli, Mariachiara, D’Alessandris, Quintino G., Giannetti, Stefano, Pacioni, Simone, Ricci-Vitiani, Lucia, Rorbach, Joanna, Pallini, Roberto, Roulland, Sandrine, Amunts, Alexey, Mancini, Ines, Modelska, Angelika, Quattrone, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097689/
https://www.ncbi.nlm.nih.gov/pubmed/33910005
http://dx.doi.org/10.1016/j.celrep.2021.109024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097689/
https://www.ncbi.nlm.nih.gov/pubmed/33910005
http://dx.doi.org/10.1016/j.celrep.2021.109024

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