Catalytic mechanism of the colistin resistance protein MCR-1

The mcr-1 gene encodes a membrane-bound Zn(2+)-metalloenzyme, MCR-1, which catalyses phosphoethanolamine transfer onto bacterial lipid A, making bacteria resistant to colistin, a last-resort antibiotic. Mechanistic understanding of this process remains incomplete. Here, we investigate possible catal...

Descripción completa

Detalles Bibliográficos
Autores principales: Suardíaz, Reynier, Lythell, Emily, Hinchliffe, Philip, van der Kamp, Marc, Spencer, James, Fey, Natalie, Mulholland, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097703/
https://www.ncbi.nlm.nih.gov/pubmed/33606866
http://dx.doi.org/10.1039/d0ob02566f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097703/
https://www.ncbi.nlm.nih.gov/pubmed/33606866
http://dx.doi.org/10.1039/d0ob02566f

Ejemplares similares