A new method for exploring gene–gene and gene–environment interactions in GWAS with tree ensemble methods and SHAP values

BACKGROUND: The identification of gene–gene and gene–environment interactions in genome-wide association studies is challenging due to the unknown nature of the interactions and the overwhelmingly large number of possible combinations. Parametric regression models are suitable to look for prespecifi...

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Detalles Bibliográficos
Autores principales: Johnsen, Pål V., Riemer-Sørensen, Signe, DeWan, Andrew Thomas, Cahill, Megan E., Langaas, Mette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097909/
https://www.ncbi.nlm.nih.gov/pubmed/33947323
http://dx.doi.org/10.1186/s12859-021-04041-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097909/
https://www.ncbi.nlm.nih.gov/pubmed/33947323
http://dx.doi.org/10.1186/s12859-021-04041-7

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