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A new method for exploring gene–gene and gene–environment interactions in GWAS with tree ensemble methods and SHAP values

BACKGROUND: The identification of gene–gene and gene–environment interactions in genome-wide association studies is challenging due to the unknown nature of the interactions and the overwhelmingly large number of possible combinations. Parametric regression models are suitable to look for prespecifi...

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Detalles Bibliográficos
Autores principales:	Johnsen, Pål V., Riemer-Sørensen, Signe, DeWan, Andrew Thomas, Cahill, Megan E., Langaas, Mette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097909/ https://www.ncbi.nlm.nih.gov/pubmed/33947323 http://dx.doi.org/10.1186/s12859-021-04041-7

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