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Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and...

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Autores principales: Ahluwalia, Tarunveer S, Prins, Bram P, Abdollahi, Mohammadreza, Armstrong, Nicola J, Aslibekyan, Stella, Bain, Lisa, Jefferis, Barbara, Baumert, Jens, Beekman, Marian, Ben-Shlomo, Yoav, Bis, Joshua C, Mitchell, Braxton D, de Geus, Eco, Delgado, Graciela E, Marek, Diana, Eriksson, Joel, Kajantie, Eero, Kanoni, Stavroula, Kemp, John P, Lu, Chen, Marioni, Riccardo E, McLachlan, Stela, Milaneschi, Yuri, Nolte, Ilja M, Petrelis, Alexandros M, Porcu, Eleonora, Sabater-Lleal, Maria, Naderi, Elnaz, Seppälä, Ilkka, Shah, Tina, Singhal, Gaurav, Standl, Marie, Teumer, Alexander, Thalamuthu, Anbupalam, Thiering, Elisabeth, Trompet, Stella, Ballantyne, Christie M, Benjamin, Emelia J, Casas, Juan P, Toben, Catherine, Dedoussis, George, Deelen, Joris, Durda, Peter, Engmann, Jorgen, Feitosa, Mary F, Grallert, Harald, Hammarstedt, Ann, Harris, Sarah E, Homuth, Georg, Hottenga, Jouke-Jan, Jalkanen, Sirpa, Jamshidi, Yalda, Jawahar, Magdalene C, Jess, Tine, Kivimaki, Mika, Kleber, Marcus E, Lahti, Jari, Liu, Yongmei, Marques-Vidal, Pedro, Mellström, Dan, Mooijaart, Simon P, Müller-Nurasyid, Martina, Penninx, Brenda, Revez, Joana A, Rossing, Peter, Räikkönen, Katri, Sattar, Naveed, Scharnagl, Hubert, Sennblad, Bengt, Silveira, Angela, Pourcain, Beate St, Timpson, Nicholas J, Trollor, Julian, van Dongen, Jenny, Van Heemst, Diana, Visvikis-Siest, Sophie, Vollenweider, Peter, Völker, Uwe, Waldenberger, Melanie, Willemsen, Gonneke, Zabaneh, Delilah, Morris, Richard W, Arnett, Donna K, Baune, Bernhard T, Boomsma, Dorret I, Chang, Yen-Pei C, Deary, Ian J, Deloukas, Panos, Eriksson, Johan G, Evans, David M, Ferreira, Manuel A, Gaunt, Tom, Gudnason, Vilmundur, Hamsten, Anders, Heinrich, Joachim, Hingorani, Aroon, Humphries, Steve E, Jukema, J Wouter, Koenig, Wolfgang, Kumari, Meena, Kutalik, Zoltan, Lawlor, Deborah A, Lehtimäki, Terho, März, Winfried, Mather, Karen A, Naitza, Silvia, Nauck, Matthias, Ohlsson, Claes, Price, Jackie F, Raitakari, Olli, Rice, Ken, Sachdev, Perminder S, Slagboom, Eline, Sørensen, Thorkild I A, Spector, Tim, Stacey, David, Stathopoulou, Maria G, Tanaka, Toshiko, Wannamethee, S Goya, Whincup, Peter, Rotter, Jerome I, Dehghan, Abbas, Boerwinkle, Eric, Psaty, Bruce M, Snieder, Harold, Alizadeh, Behrooz Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098112/
https://www.ncbi.nlm.nih.gov/pubmed/33517400
http://dx.doi.org/10.1093/hmg/ddab023